Jean Claude Reubi Selected Research

Bombesin Receptors (Bombesin Receptor)

3/2019	Localization of 99mTc-GRP Analogs in GRPR-Expressing Tumors: Effects of Peptide Length and Neprilysin Inhibition on Biological Responses.
1/2017	Approaches to improve metabolic stability of a statine-based GRP receptor antagonist.
1/2015	Evaluation of three different families of bombesin receptor radioantagonists for targeted imaging and therapy of gastrin releasing peptide receptor (GRP-R) positive tumors.
10/2014	N-terminal modifications improve the receptor affinity and pharmacokinetics of radiolabeled peptidic gastrin-releasing peptide receptor antagonists: examples of 68Ga- and 64Cu-labeled peptides for PET imaging.
1/2014	Positron emission tomography (PET) imaging of prostate cancer with a gastrin releasing peptide receptor antagonist--from mice to men.
5/2013	Targeted radiotherapy of prostate cancer with a gastrin-releasing peptide receptor antagonist is effective as monotherapy and in combination with rapamycin.
1/2013	Old and new peptide receptor targets in cancer: future directions.
1/2012	Evolution of bombesin conjugates for targeted PET imaging of tumors.
12/2011	Bombesin antagonist-based radioligands for translational nuclear imaging of gastrin-releasing peptide receptor-positive tumors.
6/2009	High expression of gastrin-releasing peptide receptors in the vascular bed of urinary tract cancers: promising candidates for vascular targeting applications.

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Jean Claude Reubi Research Topics

Disease

92	Neoplasms (Cancer) 03/2019 - 01/2002
27	Neuroendocrine Tumors (Neuroendocrine Tumor) 01/2018 - 04/2002
23	Insulinoma 09/2020 - 05/2003
7	Neoplasm Metastasis (Metastasis) 01/2015 - 05/2002
5	Pituitary Neoplasms (Pituitary Adenoma) 01/2018 - 07/2003
5	Adenocarcinoma 02/2014 - 02/2003
4	Brain Neoplasms (Brain Tumor) 01/2017 - 01/2005
4	Prostatic Neoplasms (Prostate Cancer) 01/2014 - 07/2006
4	Breast Neoplasms (Breast Cancer) 01/2013 - 01/2004
4	Thyroid Neoplasms (Thyroid Cancer) 01/2013 - 01/2007
4	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 11/2012 - 12/2011
3	Nesidioblastosis (Nesidioblastosis of Pancreas) 09/2020 - 12/2015
3	Meningioma (Meningiomas) 08/2008 - 07/2003
3	Gastrinoma 08/2007 - 05/2003
3	Pheochromocytoma 05/2007 - 12/2004
3	Ovarian Neoplasms (Ovarian Cancer) 01/2007 - 01/2004
3	Paraganglioma (Paragangliomas) 12/2005 - 07/2003
3	Neuroblastoma 12/2005 - 07/2003
3	Pancreatic Neoplasms (Pancreatic Cancer) 07/2003 - 05/2003
2	Hyperplasia 01/2020 - 01/2011
2	Renal Cell Carcinoma (Grawitz Tumor) 01/2013 - 07/2005
2	Urologic Neoplasms (Urological Cancer) 01/2013 - 06/2009
2	Lymphoma (Lymphomas) 01/2013 - 05/2007
2	Leiomyosarcoma 02/2012 - 08/2008
2	Hepatocellular Carcinoma (Hepatoma) 02/2012 - 12/2006
2	Cholangiocarcinoma 02/2012 - 12/2006
2	Carcinoma (Carcinomatosis) 04/2010 - 05/2007
2	Ewing Sarcoma (Sarcoma, Ewing) 08/2008 - 08/2004
2	Glioma (Gliomas) 08/2008 - 06/2006
2	Glioblastoma (Glioblastoma Multiforme) 08/2008 - 06/2006
2	Carcinoid Tumor (Carcinoid) 01/2007 - 01/2004
2	Ulcer 04/2006 - 03/2004
2	Stomach Ulcer (Gastric Ulcer) 04/2006 - 03/2004
2	Medulloblastoma 12/2005 - 07/2003
2	Lung Neoplasms (Lung Cancer) 09/2004 - 07/2003
2	Sarcoma (Soft Tissue Sarcoma) 08/2004 - 07/2003
1	Amaurosis Fugax 01/2017
1	Stroke (Strokes) 01/2017
1	Transient Ischemic Attack 01/2017
1	Pancreatic Ductal Carcinoma 01/2015

Drug/Important Bio-Agent (IBA)

38	Somatostatin Receptors (Somatostatin Receptor)IBA 01/2018 - 05/2002
28	Peptide Receptors (Peptide Receptor)IBA 06/2015 - 05/2003
25	Somatostatin (Somatotropin Release-Inhibiting Factor)IBA 01/2018 - 05/2002
23	Peptides (Polypeptides)IBA 03/2019 - 01/2002
18	BombesinIBA 03/2019 - 04/2002
17	Bombesin Receptors (Bombesin Receptor)IBA 03/2019 - 04/2002
16	Glucagon-Like Peptide 1 (GLP 1)IBA 01/2016 - 05/2003
13	LigandsIBA 04/2015 - 09/2002
12	1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acidIBA 01/2016 - 05/2002
12	Octreotide (Sandostatin)FDA LinkGeneric 03/2013 - 05/2002
10	Messenger RNA (mRNA)IBA 02/2012 - 04/2002
9	Glucagon-Like Peptide-1 ReceptorIBA 09/2020 - 12/2006
8	Radioisotopes (Radionuclides)IBA 03/2019 - 02/2007
8	Neuropeptide YIBA 09/2011 - 01/2004
6	Proteins (Proteins, Gene)FDA Link 02/2012 - 04/2002
6	Gastrin-Releasing PeptideIBA 07/2011 - 04/2002
5	Exenatide (Byetta)FDA Link 12/2015 - 12/2006
5	Cholecystokinin B ReceptorIBA 06/2015 - 07/2003
5	Neuropeptide Y Receptors (Neuropeptide Y Receptor)IBA 09/2011 - 01/2004
5	Cholecystokinin (Pancreozymin)IBA 11/2008 - 07/2003
4	Biological ProductsIBA 03/2019 - 08/2005
4	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2017 - 01/2008
4	gastric inhibitory polypeptide receptorIBA 01/2015 - 01/2011
4	IncretinsIBA 06/2014 - 01/2011
4	GastrinsIBA 09/2011 - 01/2007
4	AcidsIBA 06/2009 - 06/2006
4	Hormones (Hormone)IBA 01/2007 - 12/2004
3	AntibodiesIBA 01/2018 - 12/2005
3	NeurotensinIBA 01/2015 - 01/2005
3	Glucose (Dextrose)FDA LinkGeneric 01/2013 - 04/2005
3	Cholecystokinin Receptors (Cholecystokinin Receptor)IBA 02/2012 - 07/2003
3	somatostatin receptor sst2AIBA 01/2010 - 12/2005
3	Peptide YYIBA 08/2008 - 01/2004
3	secretin receptorIBA 08/2007 - 10/2005
3	Substance PIBA 06/2006 - 05/2003
2	Biomarkers (Surrogate Marker)IBA 01/2016 - 07/2011
2	1- (1,3- carboxypropyl)- 4,7- carboxymethyl- 1,4,7- triazacyclononaneIBA 01/2016 - 05/2002
2	Neurotensin Receptors (Neurotensin Receptor)IBA 01/2015 - 01/2002
2	Pentetic Acid (DTPA)FDA LinkGeneric 10/2013 - 12/2006
2	Glucagon-Like Peptides (Enteroglucagon)IBA 11/2012 - 08/2008
2	Glucagon-Like Peptide-1 Receptor AgonistsIBA 01/2012 - 11/2008
2	Chelating AgentsIBA 08/2010 - 05/2002
2	NeuropeptidesIBA 08/2008 - 08/2005
2	Secretin FDA Link 12/2006 - 10/2005
2	Protein Isoforms (Isoforms)IBA 04/2006 - 10/2005
2	Corticotropin-Releasing Hormone Receptors (Corticotropin Releasing-Hormone Receptor)IBA 01/2005 - 07/2003
2	Neurokinin-1 Receptors (Neurokinin 1 Receptor)IBA 03/2004 - 05/2003
1	Blood Glucose (Blood Sugar)IBA 09/2020
1	68Ga-DOTA-exendin-4IBA 01/2020
1	Neprilysin (Neutral Endopeptidase)IBA 03/2019
1	minigastrinIBA 06/2015
1	EstersIBA 01/2015
1	SR 48692IBA 01/2015
1	Dipeptidyl Peptidase 4 (Dipeptidyl Peptidase IV)IBA 06/2014
1	GelatinIBA 06/2014

Therapy/Procedure

32	Therapeutics 01/2020 - 05/2003
18	Radiotherapy 01/2015 - 07/2003
2	Aftercare (After-Treatment) 05/2013 - 01/2007
1	Gastric Bypass (Roux-en-Y Gastric Bypass) 01/2020
1	Carotid Endarterectomy 01/2017